Ketamine-Assisted Psychotherapy
PRISMA’s Emerging Therapies
Ketamine-Assisted Psychotherapy (KAP)
Expanding the possibilities of psychological change through the integration of neuroscience, psychotherapy, and carefully guided expanded states.
Research suggests that ketamine may temporarily increase psychological flexibility and emotional openness, creating a window in which meaningful therapeutic work can occur.
At PRISMA, KAP is not approached as a standalone medical treatment, but as a catalyst within a thoughtful psychotherapy process.
Join our waitlist for individual, couples, and group programs.
What Is Ketamine-Assisted Psychotherapy?
Ketamine-Assisted Psychotherapy (often referred to as KAP) combines the use of prescribed ketamine with psychotherapy before, during, and after the medicine session.
In traditional medical settings, ketamine has long been used as an anesthetic. More recently, research has explored its effects on mood, cognition, and emotional processing. Studies suggest that ketamine may temporarily increase neuroplasticity, which is the brain’s capacity to form new connections and patterns.
In a therapeutic context, this shift may allow people to step outside of habitual ways of thinking or feeling. Experiences that previously felt rigid or overwhelming can sometimes be approached with greater curiosity and flexibility.
When combined with psychotherapy, this period of openness can become an opportunity for meaningful psychological work.
The goal is not the medicine experience alone. The goal is the insight, integration, and change that follow.
Why Explore KAP?
People come to ketamine-assisted psychotherapy for many reasons. Often, they have already done significant personal work and are looking for a different way to move forward.
Some individuals explore KAP when they have been living with depression, trauma, emotional stuckness, or relational stress that has not shifted despite previous therapy or medication.
Many people who are curious about KAP are thoughtful, high-functioning individuals who carry significant responsibility in their professional or personal lives. They may be leaders, caregivers, or entrepreneurs who are used to operating at a high level externally while feeling that something internally remains unresolved. These individuals are seeking deeper insight and psychological flexibility.
KAP is not appropriate for everyone, and careful screening is always part of the process. For some individuals, however, it can open new possibilities within psychotherapy.
How The Process Works
Ketamine-Assisted Psychotherapy at PRISMA follows an evidence-based structured therapeutic model with three phases:
Preparation
Assessment, goal setting, psychological readiness.
Preparation sessions allow you and your therapist to build a clear understanding of your goals, personal history, and readiness for this type of work. These meetings help establish safety, trust, and intention before any medicine session takes place.
Medicine Session
Guided ketamine session with therapeutic support.
During the ketamine session, the medication is administered under the supervision of a qualified medical professional. Your treatment team remains present to provide psychological support throughout the experience.
Sessions typically unfold in a quiet and carefully designed therapeutic space that supports reflection and inward attention.
Integration
Processing insights and translating them into meaningful change.
Integration sessions take place after the medicine experience. These conversations help translate insights into lasting psychological change. Clients often explore themes, emotions, or perspectives that emerged during the session and consider how they relate to everyday life.
Many people find that integration is where the most meaningful therapeutic work occurs.
The Science
Research on ketamine for mental health has grown steadily over the past fifteen years.
Clinical studies have shown that ketamine can produce rapid antidepressant effects for some individuals, particularly those with treatment-resistant depression. Researchers are also studying how ketamine appears to influence brain networks associated with rumination, rigid thinking, and emotional distress.
Another area of interest involves neuroplasticity. Ketamine appears to temporarily increase the brain’s capacity to form new connections, which may create an opportunity for psychological learning and change.
While the field is still evolving, many clinicians and researchers believe that combining ketamine with psychotherapy holds particular promise. The medicine experience can create a window of increased openness, while psychotherapy provides the structure needed to translate that openness into insight and lasting change.
Safety And Medical Collaboration
Client safety and psychological readiness are central to the development of PRISMA’s KAP program.
Participation begins with a careful screening and assessment process. This helps determine whether Ketamine-Assisted Psychotherapy is an appropriate option based on medical history, mental health background, and personal goals.
Ketamine sessions are conducted in collaboration with a qualified medical professional who oversees the medical aspects of the treatment. Therapists remain present throughout the experience to provide psychological support and guidance.
This collaborative model allows both the medical and psychological dimensions of the work to be addressed with care, safety, and professionalism.
KAP Programs at PRISMA
Individuals
One-on-one work within an ongoing therapeutic relationship.
Individual Ketamine-Assisted Psychotherapy allows for personalized work within an ongoing therapeutic relationship. Clients and therapists can focus closely on specific patterns, emotional experiences, or life questions that are most relevant.
Groups
Small groups of 6–8 participants.
Session length approx 4 hours.
Group models can deepen integration through shared reflection and interpersonal insight.
Hearing how others reflect on their experiences can bring new perspectives and foster a sense of shared humanity that is often missing from modern life.
Couples
PRISMA is initially developing individual and small-group KAP programs, with the intention of expanding into relational and couples-based work in the future.
Couples KAP is an emerging model that may help partners step outside familiar patterns and reconnect with empathy, curiosity, and understanding.
While this offering is not yet available, it represents an area of future development for the practice.
Waitlist for KAP Programs
We anticipate launching our Ketamine-Assisted Psychotherapy program within the next several months.
Joining the waitlist allows you to:
• receive updates
• learn about group programs
• be among the first to access openings
If you are curious about this work, we invite you to leave your contact information below.
Clinician Interest
PRISMA is developing a clinically rigorous KAP program and welcomes conversations with therapists interested in this emerging field.
If you are exploring training or collaboration in psychedelic-assisted psychotherapy, we would be happy to connect.
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